effect of adenosine a1 recertors of amygdala on entorhinal cortex kindled seizures in rat

introduction: the role of adenosine a1 receptors of the amygdala on entorhinal cortex kindled seizures was investigated. material and methods: animals were kindled by daily electrical stimutation of entorhinal cortex. in the full kindled animals, n6-cyclohexyladenosine (cha 10, 50, 100, 500óm), an adenosine a1 receptor agonist and 8-cyclopentyl- 1, 3, dimethylxanthine (cpt, 10, 20 óm), an adenosine a1 receptor antagonist, were microinfused into the amygdala. results: data showed that cha, only at a concentration of 500óm, decreaed entorhinal cortex and amygdala after discharge duration, stage 5 duration and seizure duration seizure duration and increased patency to stage 4 at 15 min post drug injection. intraamygdala injection of cpt showed that it only at a concentration of 20 óm, reduced patency to stage 4. intraamygdala pretreatment of animals by intraamygdala injection of cpt (10 óm), 5 min before cha (500 óm), resulted in blockage of anticonvulsant effects of cha. conclusion: these results suggest that the amygdala may have a moderate role in seizure propagation from the entorhinal cortex and its adenosine a1 receptor activity has anticovulsant effects on entorhinal cortex kindled seizures.